Proteomická Laboratoř
Oddělení Analýzy fyziologicky aktivních látek Fyziologického ústavu AVČR, v.v.i.



Příklady publikačních výstupů


Analýza proteinů (analýza elektroforetickými a chromatografickými metodami, i ve spojení s MS)

Adam Eckhardt, Lucie Kulhava, Ivan Miksik, Statis Pataridis, Marketa Hlavackova, Jana Vasinova, Frantisek Kolar, David Sedmera, Bohuslav Ostadal: Proteomic analysis of cardiac ventricles: baso-apical differences. Molecular and Cellular Biochemistry (2018) in press.

Matej Kohutiar, Adam Eckhardt, Ivan Mikšík, Pavlína Šantorová, Jiří Wilhelm: Proteomic analysis of peroxynitrite-induced protein nitration in isolated beef heart mitochondria. Physiological Research (2018) in press.

Ivan Mikšík, Statis Paradis, Adam Eckhardt and David Sedmera: Analysis of Siamese Crocodile (Crocodylus siamensis) Eggshell Proteome. Protein J (2018) in press. https://doi.org/10.1007/s10930-017-9750-x

Mikšík, Ivan: Capillary electrochromatography of proteins and peptides (2006-2015). Journal of Separation Science, 40(1): 251-271, 2017.

Mikšík, I., Sedláková, P., Pataridis, S., Bortolotti, F. and Gottardo, R.: Proteins and their modifications in a medieval mummy. Protein Science, 25(11) (2016) 2037-2044.

Michal Jágr, Adam Eckhardt, Statis Pataridis, René Foltán, Jaroslav Myšák, Ivan Mikšík: Proteomic analysis of human tooth pulp proteomes – Comparison of caries-resistant and caries-susceptible persons, Journal of Proteomics, 145 (2016) 127-136.

Ošt’ádal, M., Eckhardt, A., Herget, J., Mikšík, I., Dungl, P., Chomiak, J., Frydrychová, M., Burian, M. Proteomic analysis of the extracellular matrix in idiopathic pes equinovarus. Molecular and Cellular Biochemistry, 401: 133-139, 2015.

Adam Eckhardt , Michal Jágr, Statis Pataridis, Ivan Mikšík: Proteomic Analysis of Human Tooth Pulp - Proteomics of Human Tooth. Journal of Endodontics. 40(12), 1961–1966, 2014.

Ivan Mikšík, Pavla Sedláková, Statis Pataridis, Federica Bortolotti, Rossella Gottardo, Franco Tagliaro: Prince Cangrande's Collagen. Study of Protein Modification on the Mummy of the Lord of Verona, Italy (1291-1329 AD). Chromatographia. 77(21-22): 1503-1510, 2014.

Miksik, Ivan; Ergang, Peter, Pacha, Jiri: Proteomic analysis of chicken eggshell cuticle membrane layer. Analytical and Bioanalytical Chemistry. 406(29): 7633-7640, 2014.

Brabcová, J., Kindl, J., Valterová, I., Pichová, I., Zarevúcka, M., Brabcová, J., Jágr, M., Mikšík, I.: Serine protease from midgut of Bombus terrestris males. Archives of Insect Biochemistry and Physiology, 82(3): 117-128, 2013.

Statis Pataridis, Zdeňka Štastná, Pavla Sedláková, Ivan Mikšík: Monotopic modifications derived from in vitro glycation of albumin with ribose. Electrophoresis, 34: 1757–1763, 2013.

Michal Jágr, Adam Eckhardt , Statis Pataridis, Ivan Mikšík: A Comprehensive Proteomic Analysis of Human Dentin. European Journal of Oral Sciences, 120: 259–268, 2012.

Katerina Lacinová, Oleg Romanov, Adam Eckhardt, Ivan Miksik, Statis Pataridis, and Pavla Sedláková: Study of saiga horn using high performance liquid chromatography with mass spectrometry. TheScientificWorldJournal, Volume 2012 (2012), Article ID 759604, 8 pages doi:10.1100/2012/759604

Lubica Grausova, Alexander Kromka, Zuzana Burdikova, Adam Eckhardt, Bohuslav Rezek, Jiri Vacik, Ken Haenen, Vera Lisa, Lucie Bacakova: Enhanced Growth and Osteogenic Differentiation of Human Osteoblast-Like Cells on Boron-Doped Nanocrystalline Diamond Thin Films. PLoS One. 2011;6(6):e20943. doi: 10.1371/journal.pone.0020943. Epub 2011 Jun 10.

Zdeňka Zmatliková, Pavla Sedláková, Katerina Lacinová, Adam Eckhardt, Statis Pataridis, Ivan Mikšík: Non-enzymatic posttranslational modifications of bovine serum albumin by oxo-compounds investigated by by high-performance liquid chromatography-mass spectrometry and capillary zone electrophoresis-mass spectrometry. J. Chromatography A, 1217 (2010) 8009–8015.

Maxová H, Bačáková L, Eckhardt A, Mikšík I, Lisá V, Novotná J, Herget J: Growth of Vascular Smooth Muscle Cells on Collagen I Exposed to RBL-2H3 Mastocytoma Cells. Cell Physiol Biochem, 25: 615-622, 2010.

Ivan Mikšík, Pavla Sedláková, Katerina Lacinová, Statis Pataridis, Adam Eckhardt: Determination of insoluble avian eggshell matrix proteins, Analytical and Bioanalytical Chemistry, 397: 205–214, 2010.

Takeshi Furuhashi, Ivan Miksik, Miloslav Smrz, Bettina Germann, Dashnor Nebija, Bodo Lachmann, Christian Noe: Comparison of Aragonitic Molluscan Shell Proteins, Comparative Biochemistry and Physiology, B 155: 195–200, 2010.

Pavla Sedláková, Adam Eckhardt, Kateřina Lacinová, Statis Pataridis, Ivan Mikšík, Vladimír Král, Václav Kašička: Separation of tryptic peptides of native and glycated bovine serum albumin using open-tubular capillary electrochromatography with salophene-lanthanide-Zn2+ complex as stationary phase. Journal of Separation Science, 32(22): 3930-3935, 2009.

Statis Pataridis, Adam Eckhardt, Katerina Mikulíková, Pavla Sedláková and Ivan Miksík: Determination and Quantification of Collagen Types in Tissues Using HPLC-MS/MS. Current Analytical Chemistry, 5(4): 316-323, 2009.

Pataridis S., Eckhardt A., Mikulíková K., Sedlakova P., Mikšík I.: Identification of collagen types in tissues using HPLC-MS/MS. J. Separ. Sci., 31:3483-3488, 2008.

K. Mikulíková, A. Eckhardt, J. Kuneš, J. Zicha, I. Mikšík: Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake. Physiological Research, 57:89-94, 2008.

Mikšík I., Sedláková P., Mikulíková K., Eckhardt A., Kašička V.: Comparison of CE-MS and HPLC-MS Analyses of Avian Eggshell Matrix Proteins. Chromatographia, 67:S89-96(Supp.1), 2008.

Mikšík I., Sedláková P.: Capillary electrochromatography of proteins and peptides. J. Sep. Sci., 30:1686-1703, 2007.

Mikulíková K., Eckhardt A., Pataridis S., Mikšík I.: Study of posttranslational non-enzymatic modifications of collagen using capillary electrophoresis/mass spectrometry and high performance liquid chromatography/mass spectrometry, J. Chromatogr. A, 1155:125-133, 2007.

Mikšík I., Eckhardt, A., Sedláková P., Mikulikova K.: Proteins of Insoluble Matrix of Avian (Gallus Gallus) Eggshell, Connective Tissue Research, 48(1):1-8, 2007.

Sedláková P., Svobodová J. and Mikšík I.: Capillary electrophoresis of peptides and proteins with plug of Pluronic gel, J. Chromatography B, 839:112-117, 2006.

Mikulíková K., Eckhardt A., Mikšík I.: Posttranslational modifications of collagen studied by off-line coupling of HPLC and CE. J. Separat. Science, 29: 1126-1131, 2006.

Mikšík I., Sedláková P., Mikulíková K., Eckhardt A.: Capillary electromigration methods for the study of collagen, J. Chromatography B, 841:3-13, 2006.

Eckhardt A., Mikšík I., Charvátová J., Deyl Z., Forgács E., Cserháti T., Proteomics of Collagen Peptides: A Method to Reveal Minor Changes in Post-Translationally Modified Collagen by HPLC and Capillary Electrophoresis. Journal of Liquid Chromatography & Related Technologies, 28:1437-1451, 2005.

Mikulíková K., Mikšík I., Deyl Z.: Non-enzymatic posttranslational modifications of bovine serum albumin by oxo-compounds investigated by chromatographic and electrophoretic methods. J. Chromatogr. B, 815:315-331, 2005.

Mikšík I., Charvátová J., Eckhardt A., Cserháti T., Forgács E., Deyl Z.: Capillary electrophoretic separation of proteins and peptides by ion-pairing with heptanesulfonic acid, Journal of Chromatography B, 800:161-167, 2004.

Ruangyuttikarn W., Miksik I., Pekkoh J., Peerapornpisal Y., Deyl Z.: RP-HPLC/MS analysis of Microcystin-LR in Cyanobacteria Blooms under alkaline conditions. J. Chromatogr. B, 800:315-319, 2004.

Mikšík I., Charvátová J., Eckhardt A., Deyl Z.: Peptide mapping by capillary electrophoresis with Pluronic F127, Journal of Chromatography B, 800:155-160, 2004.

Deyl Z., Mikšík I., Charvátová J., Eckhardt A.: Comparison of the electrophoretic separation of proteins in capillaries with different inner diameter. J. Chromatogr. A, 1013:233-238, 2003.

Charvátová J., Kasicka V., Barth T., Deyl Z., Miksík I. and Král V.: Separation of structurally related peptides by open-tubular capillary electrochromatography using (metallo)porphyrins as the adsorbed stationary phase, J. Chromatogr. A, 1009:73-80, 2003.

Cserháti T., Forgács E., Deyl Z., Miksik I., Eckhardt A.: Binding of low molecular mass compounds to proteins studied by liquid chromatographic techniques. Biomedical Chromatography, 17: 353-360, 2003.

Deyl Z., Mikšík I., Eckhardt A.: Preparative procedures and purity assessment of collagen proteins. J. Chromatogr. B, 790:245-275, 2003.

Mikšík I., Charvátová J., Eckhardt A., Deyl Z.: Insoluble eggshell matrix proteins – their peptide mapping and partial characterization. Electrophoresis, 24: 843-852, 2003.



Analýza pigmentů (analýza HPLC ve spojení s UV a MS detekcí)

Miroslav Poláček, Matteo Griggio, Ivan Mikšík, Michaela Bartíková, Manfred Eckenfellner and Herbert Hoi: Eggshell coloration and its importance in postmating sexual selection. Ecology and Evolution, 7:941-949, 2017.

Brulez, K., Mikšík, I., Cooney, C. R., Hauber, M. E., Lovell, P. G., Maurer, G., Portugal, S. J., Russell, D., Reynolds, S. J. and Cassey, P., Eggshell pigment composition covaries with phylogeny but not with life history or with nesting ecology traits of British passerines. Ecol Evol, 6: 1637–1645, 2016.

Camille Duval, Phillip Cassey, P. George Lovell, Ivan Mikšík, S. James Reynolds, Karen A. Spencer: Maternal influence on eggshell maculation: implications for cryptic camouflaged eggs. Journal of Ornithology, 157(1): 303-310, 2016.

Maurer, Golo; Miksik, Ivan; Portugal, Steven; Hauber, Mark; Russell, Douglas; Cassey, Phillip: First light for avian embryos: eggshell thickness and pigmentation mediate variation in development and UV exposure in wild bird eggs. Functional Ecology, 29: 209-218, 2015.

Camille Duval, Cédric Zimmer, Ivan Mikšík, Phillip Cassey, Karen A. Spencer: Early life stress shapes female reproductive strategy through eggshell pigmentation in Japanese quail. General and Comparative Endocrinology, 208: 146-153, 2014.

Kaat Brulez, Phillip Cassey, Alan Meeson, Ivan Mikšík, Simone L. Webber, Andrew G. Gosler and S. James Reynolds: Eggshell spot scoring methods cannot be used as a reliable proxy to determine pigment quantity. Journal of Avian Biology, 45(1): 94–102, 2014.

Camille Duval, Phillip Cassey, Paul G. Lovell, Ivan Miksik, S. James Reynolds, Karen A. Spencer: Eggshell Appearance Does Not Signal Maternal Corticosterone Exposure in Japanese Quail: An Experimental Study with Brown-Spotted Eggs. PLoS ONE 8(12): e80485. doi:10.1371/journal.pone.0080485, 2013

Juan A. Fargallo, Isabel López-Rull, Ivan Mikšík, Adam Eckhardt and Juan M. Peralta-Sánchez: Eggshell pigmentation has no evident effects on offspring viability in common kestrels. Evolutionary Ecology, 28(4): 627-637, 2014.

Camille Duval, Phillip Cassey, Ivan Miksik, James Reynolds, and Karen Spencer: Condition-dependent strategies of eggshell pigmentation: an experimental study of Japanese quail (Coturnix coturnix japonica). Journal of Experimental Biology, 216: 700-708, 2013.

Cassey, P., Mikšík, I., Portugal, S.J., Maurer, G., Ewen, J.G., Zarate, E., Sewell, M.A., Karadas, F., Grim, T., and Hauber, M.E.: Avian eggshell pigments are not consistently correlated with colour measurements or egg constituents in two Turdus thrushes. Journal of Avian Biology, 43: 503-512, 2012.

Phillip Cassey, Gavin H. Thomas, Steven J. Portugal, Golo Maurer, Mark E. Hauber, Tomáš Grim, P. George Lovell, Ivan Mikšík: Why are birds’ eggs colourful? Eggshell pigments covary with life history and nesting ecology among British breeding non-passerine birds. Biological Journal of the Linnean Society, 106:657-672, 2012.

Maurer, G., Portugal, S.J., Miksik, I. and Cassey, P.: Speckles of cryptic black-headed gull eggs show no mechanical or conductance structural function. Journal of Zoology, 285:194-204, 2011.

López-Rull I., Miksik I, Gil D.: Egg pigmentation reflects female and egg quality in the spotless starling Sturnus unicolor. Behav Ecol Sociobiol., 62(12):1877-1884, 2008

Alexandre Roulin, Bettina Almasi, Anya Rossi-Pedruzzi, Anne-Lyse Ducrest, Kazumasa Wakamatsu, Ivan Miksik, Jonathan D. Blount, Susi Jenni-Eiermann and Lukas Jenni: Corticosterone mediates the condition-dependent component of melanin-based coloration, Animal Behaviour, 75:1351-1358, 2008.



Analýzy steroidů (většinou HPLC s radioaktivní detekcí, ale i UV a MS)

Klusoňová, P., Pátková, L., Ergang, P., Mikšík, I., Zicha, J., Kuneš, J., Pácha, J.: Local metabolism of glucocorticoids in Prague hereditary hypertriglyceridemic rats - Effect of hypertriglyceridemia and gender (2011) Steroids, 76: 1252-1259, 2011.

Ergang, P., Vytáčková, K., Švec, J., Bryndová, J., Mikšík, I., Pácha, J.: Upregulation of 11ß-hydroxysteroid dehydrogenase 1 in lymphoid organs during inflammation in the rat. Journal of Steroid Biochemistry and Molecular Biology, 126(1-2): 19-25, 2011.

Vagnerová, K., Loukotová, J., Ergang, P., Musílková, J., Mikšík, I., Pácha, J.: Peroxisome proliferator-activated receptor-gamma stimulates 11ß-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells. Steroids, 76: 577-581, 2011.

Ergang, P., Leden, P., Vagnerová, K., Klusoňová, P., Mikšík, I., Jurčovičová, J., Kment, M., Pácha, J.: Local metabolism of glucocorticoids and its role in rat adjuvant arthritis Molecular and Cellular Endocrinology, 323: 155-160, 2010.

Klusonova P, Rehakova L, Borchert G, Vagnerova K, Neckar J, Ergang P, Miksik I, Kolar F, Pacha J: Chronic Intermittent Hypoxia Induces 11 beta-Hydroxysteroid Dehydrogenase in Rat Heart. Endocrinology, 150(9): 4270-4277, 2009.

Vackova, Z., Vagnerova, K., Libra, A., Miksik, I., Pacha, J., Staud, F.: Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11ß-hydroxysteroid dehydrogenase type 2 in the rat placenta. Reproductive Toxicology, 28:46-51, 2009.

Vagnerová, K., Vacková, Z., Klusonová, P., Staud, F., Kopecky, M., Ergang, P., Miksik, I., Pácha, J.: Reciprocal Changes in Maternal and Fetal Metabolism of Corticosterone in Rat During Gestation. Reproductive Sciences, 15(9): 921-931, 2008.

Klusonova, P., Kucka, M., Ergang, P., Miksik, I., Bryndova, J., Pacha J.: Cloning of chicken 11beta-hydroxysteroid dehydrogenase type 1 and its tissue distribution. J. Steroid Biochem. Molecular Biol., 111 (3-5):217-224, 2008.

Ergang, P., Leden, P., Bryndova, J., Zbankova, S., Miksik, I., Kment, M., Pacha, J.: Glucocorticoid Availability in Colonic Inflammation of Rat. Digestive Diseases and Sciences, 53:2160-2167, 2008.

Klusoňová, P., Kučka, M., Mikšík, I., Bryndová, J., Pácha, J.: Chicken 11ß-hydroxysteroid dehydrogenase type 2: Partial cloning and tissue distribution. Steroids, 73(3):348-355, 2008.

Bryndova, J., Klusonova, P., Kucka, M., Mazancova-Vagnerova, K., Miksik, I., Pacha, J.: Cloning and expression of chicken 20-hydroxysteroid dehydrogenase. Journal of Molecular Endocrinology, 37: 453-462, 2006.

K. Vagnerova, M. Kverka, P. Klusoňová, P. Ergang, I. Mikšík, H. Tlaskalová-Hogenová and J. Pácha: Intestinal inflammation modulates expression of 11beta-hydroxysteroid dehydrogenases in murine gut, Journal of Endocrinology, 191: 497-503, 2006.

M. Kučka, K. Vagnerová, P. Klusoňová, I. Mikšík and J. Pácha: Corticosterone metabolism in chicken tissues: Evidence for tissue-specific distribution of steroid dehydrogenases, General and Comparative Endocrinology, 147: 377-383, 2006.

Staud F., Mazancová K., Mikšík I., Pávek P., Fendrich Z., Pácha J.: Corticosterone transfer and metabolism in the dually perfused rat placenta: Effect of 11ß-hydroxysteroid dehydrogenase type 2. Placenta, 27: 171-180, 2006.

Mazancova K., Kopecky M., Miksik I., Pacha J.: 11 beta-Hydroxysteroid dehydrogenase in the heart of normotensive and hypertensive rats. Journal of Steroid Biochemistry and Molecular Biology, 94(1-3): 273-277, 2005.

Mazancová K., Kucka M., Miksík I., PáchaJ., Glucocorticoid metabolism and Na+ transport in chicken intestine. J. Experimental Zoology Part A: Comparative Experimental Biology, 303A (2005) 113-122.

Pácha J., Mikšík I., L. Mrnka, Z. Zemanová, J. Bryndová, K. Mazancová, M. Kucka: Corticosteroid regulation of colonic ion transport during postnatal development: Methods for corticosteroid analysis. Physiol. Res. 53(Suppl. 1):863-880, 2004.

Miksík I., Mikulíková K., Pácha J., Kucka M., Deyl Z.: Application of liquid chromatography-electrospray ionization mass spectrometry for study of steroid-converting enzymes, Journal of Chromatography B, 800:145-153, 2004.>

Mazancova K., Mikšik I., Kuneš J, Zicha J., Pácha J.: Sexual dimorphism of 11b-hydroxysteroid dehydrogenase in hypertensive and normotensive rats, Hypertens. Res., 26:333-338, 2003.

Mazancova K., Mikšik I., Kuneš J, Pácha J.: Placental 11b-hydroxysteroid dehydrogenase in Dahl and spontaneously hypertensive rats. American Journal of Hypertension, 16:401-406, 2003.



Jiné analýzy (většinou chromatografické a MS)

Jan Neckář, Adéla Boudíková, Petra Mandíková, Martin Štěrba, Olga Popelová, Ivan Mikšík, Ludmila Dabrowská, Jaroslav Mráz, Vladimír Geršl, František Kolář: Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts. Canadian Journal of Physiology and Pharmacology, 2012, 90(9): 1303-1310, 10.1139/y2012-096

Houštěk, J., Hejzlarová, K., Vrbacký, M., Drahota, Z., Landa, V., Zídek, V., Mlejnek, P., Šimáková, M., Šilhavý, J., Mikšík, I., Kazdová, L., Oliyarnyk, O., Kurtz, T., Pravenec, M. Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains (2012) Physiological Genomics, 44 (9), pp. 487-494.

Liotta, E., Gottardo, R., Seri, C., Rimondo, C., Miksik, I., Serpelloni, G., Tagliaro, F.: Rapid analysis of caffeine in "smart drugs" and "energy drinks" by microemulsion electrokinetic chromatography (MEEKC). Forensic Science International, 220: 279–283, 2012.

Gottardo, R., Mikšík, I., Aturki, Z., Sorio, D., Seri, C., Fanali, S. and Tagliaro, F.: Analysis of drugs of forensic interest with capillary zone electrophoresis/time-of-flight mass spectrometry based on the use of non-volatile buffers. Electrophoresis, 33: 599–606, 2012.

Ivan Mikšík, Kateřina Lacinová, Zdeňka Zmatlíková, Pavla Sedláková, Vladimír Král, David Sýkora, Pavel Řezanka, Václav Kašička: Open-tubular capillary electrochromatography with bare gold nanoparticles-based stationary phase applied to separation of trypsin digested native and glycated proteins. Journal of Separation Science, 35: 994-1002, 2012.

Pavel Řezanka, Sille Ehala, Jakub Koktan, David Sýkora, Pavel Žvátora, Magda Vosmanská, Vladimír Král, Ivan Mikšík, Václav Čeřovský, Václav Kašička: Application of bare gold nanoparticles in open-tubular CEC separations of polyaromatic hydrocarbons and peptides. Journal of Separation Science, 35: 73–78, 2012.

Pavel Řezanka, Klára Navrátilová, Pavel Žvátora, David Sýkora, Pavel Matějka, Ivan Mikšík, Václav Kašička and Vladimír Král: Cyclodextrin modified gold nanoparticles-based open-tubular capillary electrochromatographic separations of polyaromatic hydrocarbons. Journal of Nanoparticle Research, 13: 5947-5957, 2011.

Pavel Hyšpler, Daniel Jezbera, Tomáš Fürst, Ivan Mikšík and Maria Wacławek: Estimation of intrinsic and extrinsic environment factors of age-related tooth colour changes. Ecological Chemistry and Engineering S, 17(4): 515-525, 2010.

Tomas Jelenik, Martin Rossmeisl, Ondrej Kuda, Zuzana Macek Jilkova, Dasa Medrikova, Vladimir Kus, Michal Hensler, Petra Janovska, Ivan Miksik, Marcin Baranowski, Jan Gorski, Sophie Hébrard, Thomas E Jensen, Pavel Flachs, Simon Hawley, Benoit Viollet and Jan Kopecky: AMP-activated Protein Kinase ?2 Subunit is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids, Diabetes, 59: 2737–2746, 2010.

Antonín Klásek, Antonín Lyčka, Ivan Mikšík, Aleš Růžička: Reaction of 3-phenyl-3-aminoquinoline-2,4-diones with isothiocyanates. Facile access to novel spiro-linked 2-thioxoimidazolidine-oxindoles and imidazoline-2-thiones, Tetrahedron, 66 (11): 2015-2025, 2010.

David Sýkora, Václav Kašička, Ivan Mikšík, Pavel Řezanka, Kamil Záruba, Pavel Matějka, Vladimír Král: Application of gold nanoparticles in separation sciences, Journal of Separation Science, 33(3): 372-387, 2010.

Zdenka Prucková, Antonín Klásek, Antonín Lyčka, Ivan Mikšík, Aleš Růžička: Synthesis of 2-thioxoimidazolines via reaction of 1-unsubstituted 3-aminoquinoline-2,4-diones with isothiocyanates. Tetrahedron, 65(45): 9103-9115, 2009.

Takeshi Furuhashi, Clemes Schwarzinger, Ivan Miksik, Miloslav Smrz, Anton Beran: Molluscan shell evolution with review of shell calcification hypothesis Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 154(3): 351-371, 2009.

Klasek, A., Mrkvicka, V., Lycka, A., Miksik, I., Ruzicka, A.: Reaction of 1-substituted 3-aminoquinoline-2,4-diones with isothiocyanates. An easy pathway to generate novel 2-thioxo-1'H-spiro[imidazoline-5,3'-indole]-2,2'-diones. Tetrahedron, 65(25): 4908-4916, 2009.

Klásek, A., Lycka, A., Miksík, I., Ruzicka, A.: Molecular Rearrangement of 9b-Hydroxy-1H-imidazo[4,5-c]quinoline-2,4-diones - A Convenient Pathway to Spiro-Linked Imidazolidine-Oxindole Derivatives. Helvetica Chimica Acta, 92(4): 689-708, 2009.

Pravenec, M., Hyakukoku, M., Houstek, J., Zidek, V., Landa, V., Mlejnek, P., Miksik, I., Dudova-Mothejzikova, K., Pecina, P., Vrbacky, M., Drahota, Z., Vojtiskova, A., Mracek, T., Kazdova, L., Oliyarnyk, O., Wang, J., Ho, C., Qi, N., Sugimoto, K., Kurtz, T.: Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains, Genome Research, 17 (9), 1319-1326, 2007.

Sedláková P., Mikšík I., Gatschelhofer C., Sinner F.M., Buchmeiser M.R.: Voltage-assisted capillary LC of peptides using monolithic capillary columns prepared by ring-opening metathesis polymerization, Electrophoresis, 28:2219-2222, 2007.

Mikšík I., Sedláková P.: Capillary electrochromatography of proteins and peptides. J. Sep. Sci., 30:1686-1703, 2007.

Gottardo R., Bortolotti F., De Paoli G., Pascali J.P., Mikšík I., Tagliaro F.: Hair analysis for illicit drugs by using capillary zone electrophoresis-electrospray ionization-ion trap mass spectrometry . J. Chromatogr. A, 1159:185-189, 2007.

Šolínová V., Kašička V., Sázelová P., Barth T., Mikšík I.: Separation and investigation of structure–mobility relationship of gonadotropin-releasing hormones by capillary zone electrophoresis in conventional and isoelectric acidic background electrolytes. J. Chromatogr. A, 1155:146-153, 2007.

Sedláková P., Svobodová J., Mikšík I. and Tomás H.: Separation of poly(amidoamine) (PAMAM) dendrimer generations by dynamic coating capillary electrophoresis, J. Chromatography B, 841:135-139, 2006.

Mikšík I., Sedláková P., Mikulíková K., Eckhardt A., Cserhati T., Horváth T.: Matrices for capillary gel electrophoresis – a brief overview of uncommon gels. Biomed. Chromatogr., 20:458-465, 2006.

Deyl Z., Miksik I., Eckhardt A., Kasicka V., Král V.: Porphyrin Based Affinity Interactions: Analytical Applications with Special Reference to Open Tubular Capillary Electrochromatography. Current Analytical Chemistry, 1:103-119, 2005.

Gere-Pászti E., Cserháti T., Forgács E., Deyl, Z., Miksik I., Eckhardt A., Illes Z.: Interaction of hydroxypropy;-beta-cyclodextrin with peptides, studied by reversed-phase thin-layer chromatography. Journal of Liquid Chromatography & Related Technologies, 28: 2619-2632, 2005.

Cserháti T., Forgács E., Deyl, Z., Mikšík I.: Chromatography in authenticity and traceability tests of vegetable oils and dairy products: a review. Biomed. Chromatogr. 19: 183-190, 2005.

Veronika Řezáčová, Hana Hršelová, Hana Gryndlerová, Ivan Mikšík and Milan Gryndler: Modifications of degradation-resistant soil organic matter by soil saprobic microfungi, Soil Biology and Biochemistry, 38: 2292-2299, 2006.

Forgács E., Cserháti T., Farkas O., Eckhardt A., Miksik I., Deyl, Z.: Interaction Between Cholesterol and Non-ionic Surfactants Studied by Thin-Layer Chromatography. Journal of Liquid Chromatography & Related Technologies, 27(13): 1981-1992, 2004.

Eckhardt A., Mikšík I., Deyl Z., Charvátová J.: Separation of low-molecular mass peptides by capillary electrophoresis with the use of alkylamines as dynamic coating agents at low pH. J. Chromatogr. A, 1051: 111-117, 2004.

Matejkova O, Mustard KJ, Sponarova J, Flachs P, Rossmeisl M, Miksik I, Thomason-Hughes M, Hardie DG, Kopecky J: Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat. FEBS Letters 569: 245-248, 2004.

Cserháti T., Forgács E., Deyl, Z., Mikšík I., Eckhardt A.: Chromatographic determination of herbicide residues in various matrices. Biomed. Chromatogr. 18: 350-359, 2004.

Charvátová J., Deyl Z., Klevar M., Miksik I., Eckhardt A.: Plastic substrates based separation channels in electromigration techniques, Journal of Chromatography B, 800:161-167, 2004.

Forgács E., Cserháti T., Miksik I., Eckhardt A., Deyl Z.: Simultaneous effect of organic modifier and physicochemical parameters of barbiturates on their retention on a narrow-bore PGC column. J. Chromatogr. B, 800:259-262, 2004.

Deyl Z., Mikšík I. and Eckhardt A.: Comparison of standard capillary and chip separations of sodium dodecylsulfate-protein complexes. J. Chromatogr. A, 990: 153-158, 2003.

Cserháti T., Forgács E., Deyl Z., Mikšík I., Eckhardt A.: Binding of environmental pollutants to the corn protein zein studied by HPLC. J. Chromatogr. A, 987: 403-408, 2003.






Zpět do Proteomické laboratoře


E-mail: miksikbiomed.cas.cz